Unfractionated heparin inhibits thrombin-catalysed amplification reactions of coagulation more efficiently than those catalysed by factor Xa.

We have proposed previously that the steps in coagulation most sensitive to inhibition by heparin are the thrombin-dependent amplification reactions, and that prothrombinase is formed in heparinized plasma only after Factor Xa activates Factor VIII and Factor V. These propositions were based on the...

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Bibliografske podrobnosti
Main Authors: Ofosu, F A, Hirsh, J, Esmon, C T, Modi, G J, Smith, L M, Anvari, N, Buchanan, M R, Fenton, J W, Blajchman, M A
Format: Artigo
Jezik:Inglês
Izdano: 1989
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1135548/
https://ncbi.nlm.nih.gov/pubmed/2920007
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