The inhibition of thrombin-dependent positive-feedback reactions is critical to the expression of the anticoagulant effect of heparin.

Heparin catalyses the inhibition of two key enzymes of blood coagulation, namely Factor Xa and thrombin, by enhancing the antiproteinase activities of plasma antithrombin III and heparin cofactor II. In addition, heparin can directly inhibit the activation of Factor X and prothrombin. The contributi...

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Autors principals: Ofosu, F A, Sie, P, Modi, G J, Fernandez, F, Buchanan, M R, Blajchman, M A, Boneu, B, Hirsh, J
Format: Artigo
Idioma:Inglês
Publicat: 1987
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1147894/
https://ncbi.nlm.nih.gov/pubmed/2443128
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