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Inhibition of the amplification reactions of blood coagulation by site-specific inhibitors of alpha-thrombin.

Hirudin and hirulog-1 [D-Phe-Pro-Arg-Pro-[Gly]4-desulphohirudin-(54-65)] abrogate the enzyme activities of alpha-thrombin by binding the enzyme simultaneously at its catalytic centre and fibrin(ogen)-recognition exosite. In contrast, hirugen [hirudin-(54-65)] binds alpha-thrombin solely at the fibri...

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Detalhes bibliográficos
Main Authors: Ofosu, F A, Fenton, J W, Maraganore, J, Blajchman, M A, Yang, X, Smith, L, Anvari, N, Buchanan, M R, Hirsh, J
Formato: Artigo
Idioma:Inglês
Publicado em: 1992
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1130971/
https://ncbi.nlm.nih.gov/pubmed/1590777
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