Unfractionated heparin inhibits thrombin-catalysed amplification reactions of coagulation more efficiently than those catalysed by factor Xa.

We have proposed previously that the steps in coagulation most sensitive to inhibition by heparin are the thrombin-dependent amplification reactions, and that prothrombinase is formed in heparinized plasma only after Factor Xa activates Factor VIII and Factor V. These propositions were based on the...

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Detalhes bibliográficos
Main Authors: Ofosu, F A, Hirsh, J, Esmon, C T, Modi, G J, Smith, L M, Anvari, N, Buchanan, M R, Fenton, J W, Blajchman, M A
Formato: Artigo
Idioma:Inglês
Publicado em: 1989
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1135548/
https://ncbi.nlm.nih.gov/pubmed/2920007
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