Thrombin and factor Xa link the coagulation system with liver fibrosis

BACKGROUND: Thrombin activates hepatic stellate cells via protease-activated receptor-1. The role of Factor Xa (FXa) in hepatic fibrosis has not been elucidated. We aimed to evaluate the impact of FXa and thrombin in vitro on stellate cells and their respective inhibition in vivo using a rodent mode...

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Detalhes bibliográficos
Publicado no:BMC Gastroenterol
Main Authors: Dhar, Ameet, Sadiq, Fouzia, Anstee, Quentin M., Levene, Adam P., Goldin, Robert D., Thursz, Mark R.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5941658/
https://ncbi.nlm.nih.gov/pubmed/29739329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12876-018-0789-8
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