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Thrombin and factor Xa link the coagulation system with liver fibrosis
BACKGROUND: Thrombin activates hepatic stellate cells via protease-activated receptor-1. The role of Factor Xa (FXa) in hepatic fibrosis has not been elucidated. We aimed to evaluate the impact of FXa and thrombin in vitro on stellate cells and their respective inhibition in vivo using a rodent mode...
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| Veröffentlicht in: | BMC Gastroenterol |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BioMed Central
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5941658/ https://ncbi.nlm.nih.gov/pubmed/29739329 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12876-018-0789-8 |
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