Cellular effects of deoxynojirimycin analogues: uptake, retention and inhibition of glycosphingolipid biosynthesis

Deoxynojirimycin (DNJ) analogues are inhibitors of ceramide glucosyltransferase (CGT), which catalyses the first step in the glucosphingolipid (GSL) biosynthetic pathway. We have synthesized a series of DNJ analogues to study the contribution of N-alk(en)yl side chains (C(4), C(9) or C(18)) to the b...

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Bibliographic Details
Main Authors: Mellor, Howard R., Neville, David C. A., Harvey, David J., Platt, Frances M., Dwek, Raymond A., Butters, Terry D.
Format: Artigo
Language:Inglês
Published: Portland Press Ltd. 2004
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1133897/
https://ncbi.nlm.nih.gov/pubmed/15128268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20031822
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