Species-Independent Inhibition of Abnormal Prion Protein (PrP) Formation by a Peptide Containing a Conserved PrP Sequence

Conversion of the normal protease-sensitive prion protein (PrP) to its abnormal protease-resistant isoform (PrP-res) is a major feature of the pathogenesis associated with transmissible spongiform encephalopathy (TSE) diseases. In previous experiments, PrP conversion was inhibited by a peptide compo...

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Bibliographic Details
Main Authors: Chabry, Joëlle, Priola, Suzette A., Wehrly, Kathy, Nishio, Jane, Hope, James, Chesebro, Bruce
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1999
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC112701/
https://ncbi.nlm.nih.gov/pubmed/10400714
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