In Vivo and In Vitro Neurotoxicity of the Human Prion Protein (PrP) Fragment P118–135 Independently of PrP Expression

We recently demonstrated that the 118–135 putative transmembrane domain of prion protein (PrP) exhibited membrane fusogenic properties and induced apoptotic neuronal cell death of rat cortical neurons, independently of its aggregation state. The aim of the present study was to analyze the in vivo ne...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Chabry, Joëlle, Ratsimanohatra, Christiane, Sponne, Isabelle, Elena, Pierre-Paul, Vincent, Jean-Pierre, Pillot, Thierry
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2003
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6741883/
https://ncbi.nlm.nih.gov/pubmed/12533606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.23-02-00462.2003
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