A Recombinant Human Cytomegalovirus with a Large Deletion in UL97 Has a Severe Replication Deficiency

Human cytomegalovirus encodes a protein kinase (UL97) that confers sensitivity to ganciclovir by phosphorylating it to the monophosphate. The function of this unusual kinase in viral replication is unknown. We constructed two independent isolates of a recombinant virus, RCΔ97, that contain large del...

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Bibliographic Details
Main Authors: Prichard, Mark N., Gao, Ning, Jairath, Sanju, Mulamba, Gilbert, Krosky, Paula, Coen, Donald M., Parker, Breck O., Pari, Gregory S.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 1999
Subjects:
Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC112625/
https://ncbi.nlm.nih.gov/pubmed/10364316
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