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Lysosomotropic Agents and Cysteine Protease Inhibitors Inhibit Scrapie-Associated Prion Protein Accumulation

We report that lysosomotropic agents and cysteine protease inhibitors inhibited protease-resistant prion protein accumulation in scrapie-infected neuroblastoma cells. The inhibition occurred without either apparent effects on normal prion protein biosynthesis or turnover or direct interactions with...

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Sonraí Bibleagrafaíochta
Main Authors: Doh-ura, Katsumi, Iwaki, Toru, Caughey, Byron
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2000
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC112015/
https://ncbi.nlm.nih.gov/pubmed/10775631
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