Lysosomotropic Agents and Cysteine Protease Inhibitors Inhibit Scrapie-Associated Prion Protein Accumulation

We report that lysosomotropic agents and cysteine protease inhibitors inhibited protease-resistant prion protein accumulation in scrapie-infected neuroblastoma cells. The inhibition occurred without either apparent effects on normal prion protein biosynthesis or turnover or direct interactions with...

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Bibliografiske detaljer

Udgivet i:	J Virol
Principais autores:	Doh-ura, Katsumi, Iwaki, Toru, Caughey, Byron
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 2000
Fag:	Virus-Cell Interactions
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC112015/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10775631/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.10.4894-4897.2000
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