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pRB-Dependent, J Domain-Independent Function of Simian Virus 40 Large T Antigen in Override of p53 Growth Suppression

Simian virus 40 (SV40) large T antigen (LT) can immortalize and transform many cell types. These activities are attributed in large part to the binding and functional inactivation by LT of two major tumor suppressors: p53 and the retinoblastoma protein, pRB. Most effects of LT on pRB have been shown...

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Udgivet i:J Virol
Principais autores: Gjoerup, Ole, Chao, Herta, DeCaprio, James A., Roberts, Thomas M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2000
Fag:
Virus-Cell Interactions
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC111607/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10623749/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.2.864-874.2000
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