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pRB-Dependent, J Domain-Independent Function of Simian Virus 40 Large T Antigen in Override of p53 Growth Suppression

Simian virus 40 (SV40) large T antigen (LT) can immortalize and transform many cell types. These activities are attributed in large part to the binding and functional inactivation by LT of two major tumor suppressors: p53 and the retinoblastoma protein, pRB. Most effects of LT on pRB have been shown...

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Main Authors: Gjoerup, Ole, Chao, Herta, DeCaprio, James A., Roberts, Thomas M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2000
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Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC111607/
https://ncbi.nlm.nih.gov/pubmed/10623749
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