Inactivation of pRB-related proteins p130 and p107 mediated by the J domain of simian virus 40 large T antigen.

Inactivation of the retinoblastoma tumor suppressor protein (pRB) contributes to tumorigenesis in a wide variety of cancers. In contrast, the role of the two pRB-related proteins, p130 and p107, in oncogenic transformation is unclear. The LXCXE domain of simian virus 40 large T antigen (TAg) specifi...

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Bibliographic Details
Main Authors: Stubdal, H, Zalvide, J, Campbell, K S, Schweitzer, C, Roberts, T M, DeCaprio, J A
Format: Artigo
Language:Inglês
Published: 1997
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC232349/
https://ncbi.nlm.nih.gov/pubmed/9271376
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