Genome Replication and Progeny Virion Production of Herpes Simplex Virus Type 1 Mutants with Temperature-Sensitive Lesions in the Origin-Binding Protein

Genome replication of herpes simplex viruses (HSV) in cultured cells is thought to be started by the action of the virus-encoded origin-binding protein (OBP). In experiments using two HSV-1 mutants with temperature-sensitive lesions in the helicase domain of OBP, we demonstrated that this function i...

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Detalhes bibliográficos
Main Authors: Schildgen, Oliver, Gräper, Sascha, Blümel, Johannes, Matz, Bertfried
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1112152/
https://ncbi.nlm.nih.gov/pubmed/15890967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.11.7273-7278.2005
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