Role of Herpes Simplex Virus ICP27 in the Degradation of mRNA by Virion Host Shutoff RNase

The virion host shutoff (VHS) RNase tegument protein released into cells by infecting virus has two effects. Preexisting stable mRNAs (e.g., GAPDH [glyceraldehyde-3-phosphate dehydrogenase]) are rapidly degraded. Stress response RNAs containing AU-rich elements (AREs) in the 3′ untranslated region (...

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Détails bibliographiques
Auteurs principaux: Taddeo, Brunella, Zhang, Weiran, Roizman, Bernard
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 2010
Sujets:
Genome Replication and Regulation of Viral Gene Expression
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937800/
https://ncbi.nlm.nih.gov/pubmed/20631134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00975-10
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