Role of Herpes Simplex Virus ICP27 in the Degradation of mRNA by Virion Host Shutoff RNase

The virion host shutoff (VHS) RNase tegument protein released into cells by infecting virus has two effects. Preexisting stable mRNAs (e.g., GAPDH [glyceraldehyde-3-phosphate dehydrogenase]) are rapidly degraded. Stress response RNAs containing AU-rich elements (AREs) in the 3′ untranslated region (...

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Bibliographische Detailangaben
Hauptverfasser: Taddeo, Brunella, Zhang, Weiran, Roizman, Bernard
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2010
Schlagworte:
Genome Replication and Regulation of Viral Gene Expression
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937800/
https://ncbi.nlm.nih.gov/pubmed/20631134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00975-10
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