Role of Herpes Simplex Virus ICP27 in the Degradation of mRNA by Virion Host Shutoff RNase

The virion host shutoff (VHS) RNase tegument protein released into cells by infecting virus has two effects. Preexisting stable mRNAs (e.g., GAPDH [glyceraldehyde-3-phosphate dehydrogenase]) are rapidly degraded. Stress response RNAs containing AU-rich elements (AREs) in the 3′ untranslated region (...

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Detalhes bibliográficos
Main Authors: Taddeo, Brunella, Zhang, Weiran, Roizman, Bernard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937800/
https://ncbi.nlm.nih.gov/pubmed/20631134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00975-10
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