Herpes Simplex Virus Mutants with Multiple Substitutions Affecting DNA Binding of UL42 Are Impaired for Viral Replication and DNA Synthesis

Herpes simplex virus mutants with single substitutions that decrease DNA binding by the DNA polymerase processivity subunit UL42 are only modestly impaired for viral replication. In this study, recombinant viruses harboring two or four of these mutations were constructed. The more substitutions, the...

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Détails bibliographiques
Auteurs principaux: Jiang, Changying, Hwang, Ying T., Wang, Guangliang, Randell, John C. W., Coen, Donald M., Hwang, Charles B. C.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology (ASM) 2007
Sujets:
Genome Replication and Regulation of Viral Gene Expression
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2168780/
https://ncbi.nlm.nih.gov/pubmed/17715219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01133-07
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