Herpes Simplex Virus Mutants with Multiple Substitutions Affecting DNA Binding of UL42 Are Impaired for Viral Replication and DNA Synthesis

Herpes simplex virus mutants with single substitutions that decrease DNA binding by the DNA polymerase processivity subunit UL42 are only modestly impaired for viral replication. In this study, recombinant viruses harboring two or four of these mutations were constructed. The more substitutions, the...

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Bibliographic Details
Main Authors: Jiang, Changying, Hwang, Ying T., Wang, Guangliang, Randell, John C. W., Coen, Donald M., Hwang, Charles B. C.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2007
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2168780/
https://ncbi.nlm.nih.gov/pubmed/17715219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01133-07
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