The p53 Tumor Suppressor Protein Does Not Regulate Expression of Its Own Inhibitor, MDM2, Except under Conditions of Stress

MDM2 is an important regulator of the p53 tumor suppressor protein. MDM2 inhibits p53 by binding to it, physically blocking its ability to transactivate gene expression, and stimulating its degradation. In cultured cells, mdm2 expression can be regulated by p53. Hence, mdm2 and p53 can interact to f...

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發表在:	Mol Cell Biol
Principais autores:	Mendrysa, Susan M., Perry, Mary Ellen
格式:	Artigo
語言:	Inglês
出版:	Taylor & Francis 2000
主題:	Transcriptional Regulation
在線閱讀:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC110819/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10688649/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.6.2023-2030.2000
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