The p53 Tumor Suppressor Protein Does Not Regulate Expression of Its Own Inhibitor, MDM2, Except under Conditions of Stress

MDM2 is an important regulator of the p53 tumor suppressor protein. MDM2 inhibits p53 by binding to it, physically blocking its ability to transactivate gene expression, and stimulating its degradation. In cultured cells, mdm2 expression can be regulated by p53. Hence, mdm2 and p53 can interact to f...

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Dades bibliogràfiques

Publicat a:	Mol Cell Biol
Autors principals:	Mendrysa, Susan M., Perry, Mary Ellen
Format:	Artigo
Idioma:	Inglês
Publicat:	Taylor & Francis 2000
Matèries:	Transcriptional Regulation
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC110819/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10688649/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.6.2023-2030.2000
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