The p53 Tumor Suppressor Protein Does Not Regulate Expression of Its Own Inhibitor, MDM2, Except under Conditions of Stress

MDM2 is an important regulator of the p53 tumor suppressor protein. MDM2 inhibits p53 by binding to it, physically blocking its ability to transactivate gene expression, and stimulating its degradation. In cultured cells, mdm2 expression can be regulated by p53. Hence, mdm2 and p53 can interact to f...

ver descrição completa

Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Mendrysa, Susan M., Perry, Mary Ellen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2000
Assuntos:	Transcriptional Regulation
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC110819/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10688649/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.6.2023-2030.2000
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!