Novel Gag-Pol Frameshift Site in Human Immunodeficiency Virus Type 1 Variants Resistant to Protease Inhibitors

Human immunodeficiency virus type 1 (HIV-1) variants resistant to protease inhibitors have been shown to contain a mutation in the p1/p6 Gag precursor cleavage site. At the messenger RNA level, this mutation generates a U UUU UUU sequence that is reminiscent of the U UUU UUA sequence required for ri...

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Bibliographic Details
Main Authors: Doyon, Louise, Payant, Catherine, Brakier-Gingras, Léa, Lamarre, Daniel
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1998
Subjects:
Animal Viruses
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC110421/
https://ncbi.nlm.nih.gov/pubmed/9621079
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