Retracing the Evolutionary Pathways of Human Immunodeficiency Virus Type 1 Resistance to Protease Inhibitors: Virus Fitness in the Absence and in the Presence of Drug

Human immunodeficiency virus type 1 (HIV-1) resistance to protease inhibitors (PI) is a major obstacle to the full success of combined antiretroviral therapy. High-level resistance to these compounds is the consequence of stepwise accumulation of amino acid substitutions in the HIV-1 protease (PR),...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Mammano, Fabrizio, Trouplin, Virginie, Zennou, Veronique, Clavel, Francois
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2000
Assuntos:	Recombination and Evolution
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC116364/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10954553/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.74.18.8524-8531.2000
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