Resistance-Associated Loss of Viral Fitness in Human Immunodeficiency Virus Type 1: Phenotypic Analysis of Protease and gag Coevolution in Protease Inhibitor-Treated Patients

We have studied the phenotypic impact of adaptative Gag cleavage site mutations in patient-derived human immunodeficiency virus type 1 (HIV-1) variants having developed resistance to the protease inhibitor ritonavir or saquinavir. We found that Gag mutations occurred in a minority of resistant virus...

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Pubblicato in:	J Virol
Autori principali:	Mammano, Fabrizio, Petit, Caroline, Clavel, François
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1998
Soggetti:	Viral Pathogenesis and Immunity
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC110025/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9696866/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.72.9.7632-7637.1998
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