Immunomodulatory oligonucleotides containing a cytosine-phosphate-2′-deoxy-7-deazaguanosine motif as potent Toll-like receptor 9 agonists

Bacterial DNA and synthetic oligomers containing CpG dinucleotides activate the immune system through Toll-like receptor (TLR) 9. Here, we compare the immunostimulatory activity of three immunomers with different nucleotide sequences containing a synthetic cytosine-phosphate-2′-deoxy-7-deazaguanosin...

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Detalhes bibliográficos
Main Authors: Kandimalla, Ekambar R., Bhagat, Lakshmi, Li, Yukui, Yu, Dong, Wang, Daqing, Cong, Yan-Ping, Song, Sam S., Tang, Jimmy X., Sullivan, Tim, Agrawal, Sudhir
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1100782/
https://ncbi.nlm.nih.gov/pubmed/15860583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0501729102
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