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Design, synthesis and biological evaluation of novel antagonist compounds of Toll-like receptors 7, 8 and 9
Oligonucleotides containing an immune-stimulatory motif and an immune-regulatory motif act as antagonists of Toll-like receptor (TLR)7 and TLR9. In the present study, we designed and synthesized oligonucleotide-based antagonists of TLR7, 8 and 9 containing a 7-deaza-dG or arabino-G modification in t...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3616729/ https://ncbi.nlm.nih.gov/pubmed/23396449 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt078 |
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