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Design, synthesis and biological evaluation of novel antagonist compounds of Toll-like receptors 7, 8 and 9

Oligonucleotides containing an immune-stimulatory motif and an immune-regulatory motif act as antagonists of Toll-like receptor (TLR)7 and TLR9. In the present study, we designed and synthesized oligonucleotide-based antagonists of TLR7, 8 and 9 containing a 7-deaza-dG or arabino-G modification in t...

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Autors principals: Kandimalla, Ekambar R., Bhagat, Lakshmi, Wang, Daqing, Yu, Dong, Sullivan, Tim, La Monica, Nicola, Agrawal, Sudhir
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3616729/
https://ncbi.nlm.nih.gov/pubmed/23396449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt078
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