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Stabilized immune modulatory RNA compounds as agonists of Toll-like receptors 7 and 8
Viral and synthetic single-stranded RNAs are the ligands for Toll-like receptor (TLR)7 and TLR8. However, single-stranded RNA is rapidly degraded by ubiquitous RNases, and the studies reported to date have used RNA with lipid carriers. To overcome nuclease susceptibility of RNA, we have synthesized...
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| Autors principals: | , , , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2007
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1959454/ https://ncbi.nlm.nih.gov/pubmed/17698957 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0706059104 |
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