Stabilized immune modulatory RNA compounds as agonists of Toll-like receptors 7 and 8

Viral and synthetic single-stranded RNAs are the ligands for Toll-like receptor (TLR)7 and TLR8. However, single-stranded RNA is rapidly degraded by ubiquitous RNases, and the studies reported to date have used RNA with lipid carriers. To overcome nuclease susceptibility of RNA, we have synthesized...

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Detalhes bibliográficos
Main Authors: Lan, Tao, Kandimalla, Ekambar R., Yu, Dong, Bhagat, Lakshmi, Li, Yukui, Wang, Daqing, Zhu, FuGang, Tang, Jimmy X., Putta, Mallikarjuna R., Cong, YanPing, Trombino, Anthony F., Sullivan, Tim, Agrawal, Sudhir
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2007
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1959454/
https://ncbi.nlm.nih.gov/pubmed/17698957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0706059104
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