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Dissociation of the CD4 and CXCR4 Binding Properties of Human Immunodeficiency Virus Type 1 gp120 by Deletion of the First Putative Alpha-Helical Conserved Structure

To evaluate conserved structures of the surface gp120 subunit (SU) of the human immunodeficiency virus type 1 (HIV-1) envelope in gp120-cell interactions, we designed and produced an HIV-1 IIIB (HXB2R) gp120 carrying a deletion of amino acids E61 to S85. This sequence corresponds to a highly conserv...

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Detalhes bibliográficos
Main Authors: Missé, Dorothée, Cerutti, Martine, Schmidt, Isabelle, Jansen, Aline, Devauchelle, Gérard, Jansen, Franz, Veas, Francisco
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1998
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC109951/
https://ncbi.nlm.nih.gov/pubmed/9696823
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