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T-Cell-Line-Tropic Human Immunodeficiency Virus Type 1 That Is Made Resistant to Stromal Cell-Derived Factor 1α Contains Mutations in the Envelope gp120 but Does Not Show a Switch in Coreceptor Use

The NL4.3 T-cell-line-tropic human immunodeficiency virus type 1 strain is sensitive to the CXC chemokine stromal cell-derived factor 1α (SDF-1α), the natural ligand for CXC chemokine receptor 4 (CXCR4); the 50% inhibitory concentration (IC(50)) in MT-4 cells is 130 ng/ml. We generated resistant vir...

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書誌詳細
主要な著者: Schols, Dominique, Esté, José A., Cabrera, Cecilia, De Clercq, Erik
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 1998
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC109631/
https://ncbi.nlm.nih.gov/pubmed/9557691
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