Functional Mimicry of a Human Immunodeficiency Virus Type 1 Coreceptor by a Neutralizing Monoclonal Antibody

Interaction of the human immunodeficiency virus type 1 (HIV-1) gp120 envelope glycoprotein with the primary receptor, CD4, promotes binding to a chemokine receptor, either CCR5 or CXCR4. The chemokine receptor-binding site on gp120 elicits CD4-induced (CD4i) antibodies in some HIV-1-infected individ...

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Autores principales: Xiang, Shi-Hua, Farzan, Michael, Si, Zhihai, Madani, Navid, Wang, Liping, Rosenberg, Eric, Robinson, James, Sodroski, Joseph
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2005
Materias:
Vaccines and Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1091675/
https://ncbi.nlm.nih.gov/pubmed/15857992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.10.6068-6077.2005
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