The MYND Motif Is Required for Repression of Basal Transcription from the Multidrug Resistance 1 Promoter by the t(8;21) Fusion Protein

Chromosomal translocations in acute leukemia that affect the AML-1/CBFβ transcription factor complex create dominant inhibitory proteins. However, the mechanisms by which these proteins act remain obscure. Here we demonstrate that the multidrug resistance 1 (MDR-1) promoter is a target for AML/ETO t...

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Bibliographic Details
Main Authors: Lutterbach, Bart, Sun, Daxi, Schuetz, John, Hiebert, Scott W.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1998
Subjects:
Transcriptional Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC108942/
https://ncbi.nlm.nih.gov/pubmed/9584201
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