XRCC1 Is Specifically Associated with Poly(ADP-Ribose) Polymerase and Negatively Regulates Its Activity following DNA Damage

Poly(ADP-ribose) polymerase (PARP; EC 2.4.2.30) is a zinc-finger DNA-binding protein that detects and signals DNA strand breaks generated directly or indirectly by genotoxic agents. In response to these breaks, the immediate poly(ADP-ribosyl)ation of nuclear proteins involved in chromatin architectu...

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Bibliographische Detailangaben
Hauptverfasser: Masson, Murielle, Niedergang, Claude, Schreiber, Valérie, Muller, Sylviane, Menissier-de Murcia, Josiane, de Murcia, Gilbert
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 1998
Schlagworte:
DNA Dynamics and Chromosome Structure
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC108937/
https://ncbi.nlm.nih.gov/pubmed/9584196
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