A Naturally Occurring hPMS2 Mutation Can Confer a Dominant Negative Mutator Phenotype

Defects in mismatch repair (MMR) genes result in a mutator phenotype by inducing microsatellite instability (MI), a characteristic of hereditary nonpolyposis colorectal cancers (HNPCC) and a subset of sporadic colon tumors. Present models describing the mechanism by which germ line mutations in MMR...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Nicolaides, Nicholas C., Littman, Susan J., Modrich, Paul, Kinzler, Kenneth W., Vogelstein, Bert
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 1998
Gaiak:
DNA Dynamics and Chromosome Structure
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC108878/
https://ncbi.nlm.nih.gov/pubmed/9488480
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