A Naturally Occurring hPMS2 Mutation Can Confer a Dominant Negative Mutator Phenotype

Defects in mismatch repair (MMR) genes result in a mutator phenotype by inducing microsatellite instability (MI), a characteristic of hereditary nonpolyposis colorectal cancers (HNPCC) and a subset of sporadic colon tumors. Present models describing the mechanism by which germ line mutations in MMR...

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Hlavní autoři: Nicolaides, Nicholas C., Littman, Susan J., Modrich, Paul, Kinzler, Kenneth W., Vogelstein, Bert
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 1998
Témata:
DNA Dynamics and Chromosome Structure
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC108878/
https://ncbi.nlm.nih.gov/pubmed/9488480
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