A specific subdomain in φ29 DNA polymerase confers both processivity and strand-displacement capacity

Recent crystallographic studies of φ29 DNA polymerase have provided structural insights into its strand displacement and processivity. A specific insertion named terminal protein region 2 (TPR2), present only in protein-primed DNA polymerases, together with the exonuclease, thumb, and palm subdomain...

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Main Authors: Rodríguez, Irene, Lázaro, José M., Blanco, Luis, Kamtekar, Satwik, Berman, Andrea J., Wang, Jimin, Steitz, Thomas A., Salas, Margarita, de Vega, Miguel
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2005
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1088371/
https://ncbi.nlm.nih.gov/pubmed/15845765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0500597102
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