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The φ29 DNA polymerase:protein-primer structure suggests a model for the initiation to elongation transition

The absolute requirement for primers in the initiation of DNA synthesis poses a problem for replicating the ends of linear chromosomes. The DNA polymerase of bacteriophage φ29 solves this problem by using a serine hydroxyl of terminal protein to prime replication. The 3.0 Å resolution structure show...

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Hlavní autoři: Kamtekar, Satwik, Berman, Andrea J, Wang, Jimin, Lázaro, José M, de Vega, Miguel, Blanco, Luis, Salas, Margarita, Steitz, Thomas A
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1422159/
https://ncbi.nlm.nih.gov/pubmed/16511564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7601027
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