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A brain detoxifying enzyme for organophosphorus nerve poisons

Organophosphorus (OP) insecticides and chemical warfare agents act primarily by inhibiting acetylcholinesterase. There are many secondary targets for OP toxicants as observed for example with the major insecticide chlorpyrifos and its bioactivated metabolite chlorpyrifos oxon (CPO). Therefore, it wa...

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Detalhes bibliográficos
Main Authors: Nomura, Daniel K., Leung, Donmienne, Chiang, Kyle P., Quistad, Gary B., Cravatt, Benjamin F., Casida, John E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1087944/
https://ncbi.nlm.nih.gov/pubmed/15840715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0501915102
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