A brain detoxifying enzyme for organophosphorus nerve poisons

Organophosphorus (OP) insecticides and chemical warfare agents act primarily by inhibiting acetylcholinesterase. There are many secondary targets for OP toxicants as observed for example with the major insecticide chlorpyrifos and its bioactivated metabolite chlorpyrifos oxon (CPO). Therefore, it wa...

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Bibliografiske detaljer
Main Authors: Nomura, Daniel K., Leung, Donmienne, Chiang, Kyle P., Quistad, Gary B., Cravatt, Benjamin F., Casida, John E.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2005
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1087944/
https://ncbi.nlm.nih.gov/pubmed/15840715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0501915102
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