Inhibitory Effect of 2′-Substituted Nucleosides on Hepatitis C Virus Replication Correlates with Metabolic Properties in Replicon Cells

Nucleosides have been widely used in the treatment of viral diseases, but relatively few have been identified as inhibitors of hepatitis C virus (HCV). The modified ribonucleosides, 2′-C-methyl-adenosine and 2′-O-methyl-cytidine, are potent inhibitors of HCV replication which specifically target the...

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Autores principales: Tomassini, Joanne E., Getty, Krista, Stahlhut, Mark W., Shim, Sung, Bhat, Balkrishen, Eldrup, Anne B., Prakash, Thazha P., Carroll, Steven S., Flores, Osvaldo, MacCoss, Malcolm, McMasters, Daniel R., Migliaccio, Giovanni, Olsen, David B.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2005
Materias:
Antiviral Agents
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1087620/
https://ncbi.nlm.nih.gov/pubmed/15855531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.5.2050-2058.2005
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