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Brain plasmin enhances APP α-cleavage and Aβ degradation and is reduced in Alzheimer’s disease brains
The proteolytic processing of amyloid precursor protein (APP) has been linked to sphingolipid-cholesterol microdomains (rafts). However, the raft proteases that may be involved in APP cleavage have not yet been identified. In this work we present evidence that the protease plasmin is restricted to r...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1083779/ https://ncbi.nlm.nih.gov/pubmed/11263499 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/embo-reports/kvd107 |
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