Neuronal membrane cholesterol loss enhances amyloid peptide generation

Recent experimental and clinical retrospective studies support the view that reduction of brain cholesterol protects against Alzheimer's disease (AD). However, genetic and pharmacological evidence indicates that low brain cholesterol leads to neurodegeneration. This apparent contradiction promp...

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Detalhes bibliográficos
Main Authors: Abad-Rodriguez, Jose, Ledesma, Maria Dolores, Craessaerts, Katleen, Perga, Simona, Medina, Miguel, Delacourte, Andre, Dingwall, Colin, De Strooper, Bart, Dotti, Carlos G.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2004
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172459/
https://ncbi.nlm.nih.gov/pubmed/15583033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200404149
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