Neuronal membrane cholesterol loss enhances amyloid peptide generation

Recent experimental and clinical retrospective studies support the view that reduction of brain cholesterol protects against Alzheimer's disease (AD). However, genetic and pharmacological evidence indicates that low brain cholesterol leads to neurodegeneration. This apparent contradiction promp...

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Autori principali: Abad-Rodriguez, Jose, Ledesma, Maria Dolores, Craessaerts, Katleen, Perga, Simona, Medina, Miguel, Delacourte, Andre, Dingwall, Colin, De Strooper, Bart, Dotti, Carlos G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2004
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172459/
https://ncbi.nlm.nih.gov/pubmed/15583033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200404149
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