The role of seladin-1/DHCR24 in cholesterol biosynthesis, APP processing and Aβ generation in vivo

The cholesterol-synthesizing enzyme seladin-1, encoded by the Dhcr24 gene, is a flavin adenine dinucleotide-dependent oxidoreductase and regulates responses to oncogenic and oxidative stimuli. It has a role in neuroprotection and is downregulated in affected neurons in Alzheimer's disease (AD)....

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Hauptverfasser: Crameri, Arames, Biondi, Elisa, Kuehnle, Katrin, Lütjohann, Dieter, Thelen, Karin M, Perga, Simona, Dotti, Carlos G, Nitsch, Roger M, Ledesma, Maria Dolores, Mohajeri, M Hasan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2006
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1383521/
https://ncbi.nlm.nih.gov/pubmed/16407971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600938
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