Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signaling

Using the OP9-DL1 system to deliver temporally controlled Notch/Delta signaling, we show that pluripotent hematolymphoid progenitors undergo T-lineage specification and B-lineage inhibition in response to Notch signaling in a delayed and asynchronous way. Highly enriched progenitors from fetal liver...

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Bibliographic Details
Main Authors: Taghon, Tom N., David, Elizabeth-Sharon, Zúñiga-Pflücker, Juan Carlos, Rothenberg, Ellen V.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2005
Subjects:
Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1080135/
https://ncbi.nlm.nih.gov/pubmed/15833919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1298305
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