Notch/Delta signaling constrains reengineering of pro-T cells by PU.1

PU.1 is essential for early stages of mouse T cell development but antagonizes it if expressed constitutively. Two separable mechanisms are involved: attenuation and diversion. Dysregulated PU.1 expression inhibits pro-T cell survival, proliferation, and passage through β-selection by blocking essen...

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Autori principali: Franco, Christopher B., Scripture-Adams, Deirdre D., Proekt, Irina, Taghon, Tom, Weiss, Angela H., Yui, Mary A., Adams, Stephanie L., Diamond, Rochelle A., Rothenberg, Ellen V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2006
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1567686/
https://ncbi.nlm.nih.gov/pubmed/16880393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0601188103
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