Lentiviral transduction of Tar Decoy and CCR5 ribozyme into CD34+ progenitor cells and derivation of HIV-1 resistant T cells and macrophages

BACKGROUND: RNA based antiviral approaches against HIV-1 are among the most promising for long-term gene therapy. These include ribozymes, aptamers (decoys), and small interfering RNAs (siRNAs). Lentiviral vectors are ideal for transduction of such inhibitory RNAs into hematopoietic stem cells due t...

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Main Authors: Banerjea, Akhil, Li, Ming-Jie, Remling, Leila, Rossi, John, Akkina, Ramesh
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2004
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1074342/
https://ncbi.nlm.nih.gov/pubmed/15813986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-6405-1-2
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