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Topoisomerase I Amino Acid Substitutions, Gly185Arg and Asp325Glu, Confer Camptothecin Resistance in Leishmania donovani
The antitumor compound camptothecin (CPT) is also recognized for its specific activity against Leishmania donovani topoisomerase I (Topo-I). In consequence, defining CPT resistance mechanisms represents an important strategic tool in the acquisition of a better understanding of its mode of action. I...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Microbiology
2005
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1068627/ https://ncbi.nlm.nih.gov/pubmed/15793124 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.4.1441-1446.2005 |
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