Topoisomerase I Amino Acid Substitutions, Gly185Arg and Asp325Glu, Confer Camptothecin Resistance in Leishmania donovani

The antitumor compound camptothecin (CPT) is also recognized for its specific activity against Leishmania donovani topoisomerase I (Topo-I). In consequence, defining CPT resistance mechanisms represents an important strategic tool in the acquisition of a better understanding of its mode of action. I...

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Bibliografiska uppgifter
Huvudupphovsmän: Marquis, Jean-François, Hardy, Isabelle, Olivier, Martin
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2005
Ämnen:
Mechanisms of Resistance
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1068627/
https://ncbi.nlm.nih.gov/pubmed/15793124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.4.1441-1446.2005
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